Activon Medical Grade Manuka Honey 25g (Pack of 3)

Product Information

Twist off the cap and apply to the wound bed to a minimum depth of 5mm and cover with an appropriate secondary dressing. Activon Tube is a single patient use only product, once opened use within 90 days. Zone of inhibition induced by the herbal gel formulation was greater than honey alone (35.1 mm vs 13.1 mm respectively). Activon Tube is ideal for debriding necrotic tissue, or for topping up dressings where the honey has been washed away by exudate. Great for using in cavities, just wash away with saline solution. PROs Medical grade honey is manuka honey that has been was sterilized from all impurities and microorganisms (spores). Activon Tube contains 100% Manuka honey with no additives from New Zealand. Our Manuka honey is filtered and sterilised, making it suitable for application to wounds. Manuka honey will de-bride and de-slough, eliminate odours and provides a moist wound healing environment. Activon Tube is ideal for debriding necrotic tissue, or for topping up dressings where the honey has been washed away by exudate. Great for using in cavities, just wash away with saline solution. How to useActivon Medical Grade Manuka Honey

Other researchers support the occurrence of enhanced effects of honey and antibiotics. Klein et al (2020) 31 used a broth culture assay to investigate the ability of subinhibitory concentrations of a range of medical grade honeys (Comvita ® Manuka Medihoney ®; Comvita ® Medihoney ® Antibacterial Wound Gel™; Revamil ® gel; and Surgihoney™RO ®) to enhance the activity of antibiotics (tetracycline, sulphatriad, streptomycin, penicillin G, chloramphenicol and ampicillin) against S. aureus and P. aeruginosa. In their study, bacteria were incubated aerobically overnight in broth cultures containing 10% honey. Samples from these cultures were then spread onto TSA plates and antibiotic discs (Mastring-S, Mast Group Ltd) were added to the agar and incubated at 37°C. The researchers found that the ability of the honeys to enhance the activity of the antibiotic depended on the type of honey, the antibiotic, and the bacterial species. Their key findings were that Surgihoney™RO ® and Comvita ® Medihoney ® Antibacterial Wound Gel™ increased the activity of tetracycline and ampicillin against S. aureus and increased the activity of tetracycline against P. aeruginosa.Surgihoney™RO ® and Comvita ®Medihoney ® Antibacterial Wound Gel™ increased the sensitivity of S. aureus to tetracycline and ampicillin.

Activon honey is a medical grade honey for wounds, produced by Advancis Medical from manuka honey, New Zealand. When shall we use it? Low pH. Usually between 3.3 and 4.6, with some exception: chestnut honey (pH, between 5 and 6) and honeydew honey (pH between 4.5 and 6.5). Other therapeutic agents being considered for use in combination with honey for the treatment of wounds include honey and bacteriophage therapy, honey supplemented with antimicrobial peptides, honey combined with cyclodextrins or hydrogel, or honey and laser therapy. Novel approaches to wound healing have involved adding a combination of antimicrobial agents to nanofibrous scaffolds. For example, Sarhan and Azzazy (2017) 50 reported that honey (Egyptian clover) (30%) chitosan nanofibers loaded with bee venom (0.01%) and bacteriophages had superior antimicrobial activity in a broth culture assay against MDR P. aeruginosa in comparison to ionic silver containing Aquacel-Ag wound dressing. Furthermore, the novel honey bacteriophage dressing demonstrated better wound healing ability in mice when compared to Aquacel-Ag wound dressing. Oliveira et al (2017) 51 also reported synergistic antimicrobial effects against E. coli biofilms formed on 96 well plates at 12 and 24 hours using multi-floral Portuguese honey and an E. coli specific bacteriophage. This approach combines the antibiofilm effects of honey with the ability of bacteriophages to lyse bacteria. Scanning electron microscopy revealed that honey caused perturbations in the membrane of the E. coli whilst the bacteriophage caused complete lysis with only vesicle structures left behind.MGO -methylglyoxal. Found in larger quantities in manuka honey and kanuka honey, this is MGO is a substance with high antibacterial properties. The quantity of MGO found in Manuka Honey is expressed in UMF – Unique Manuka Factor. Can we use any type of honey? Wear time will depend on the level of exudate but Eclypse can be left in place for up to seven days. Eclypse can be used under compression therapy. L-Mesitran demonstrated antifungal activity against C. albicans (MIC 25%–50%), whereas 40% Mexican yucatan honey did not. From this point of view it is safer to use it on any kind of wound, no matter how deep it is. What is Activon?

Hydrogel is commonly used as a wound dressing. It is composed of polymers suspended in water and is thought to provide hydration to a wound and promote healing. El-Kased et al (2017) 53 reported that an Egyptian honey (75%) chitosan hydrogel formula had superior antimicrobial activity against P. aeruginosa, S. aureus, K. pneumonia and Streptococcus pyogenes in a disc diffusion assay in comparison to pure honey. For example, the mean zone of inhibition for the honey 75% chitosan hydrogel formula against S. aureus was 20.2 ± 0.4 vs 15.1 ± 0.9 for honey. This formula was also superior to pure honey in the healing of 10 mm burn wounds induced in mice using a heated metallic rod. The wounds were treated with either the honey 75% chitosan hydrogel formula or honey for 9 days. By day 9, the honey chitosan treated wounds had a mean diameter of 3.8 ± 0.2 mm versus 5.3 ± 0.8 mm in the honey only treated group. Furthermore, an alginate-based honey hydrogel containing thymol-based honey from Damavand, Iran was reported to have superior wound healing ability in rats with infected burn wounds than honey alone. 54 Wound healing was faster in the alginate-based honey hydrogel treated group in comparison to the honey only group. In another study, a paste composed of carboxymethyl cellulose hydrogel (50%), water (30%) and chestnut honey (20%) had superior antimicrobial activity against S. aureus and E.coli in a disc diffusion assay than a paste composed of carboxymethyl cellulose hydrogel (50%) and water only. 55 Furthermore, the paste containing 20% chestnut honey had superior wound healing ability in comparison to the paste without honey in the treatment of wounds inflicted in the dorsal skin of mice. Tavaloki and Tang (2017) 56 designed a wound dressing consisting of a high concentration of honey, polyvinyl alcohol hybrid hydrogel and borax as a crosslinking agent. High concentrations of honey are important for wound healing but can negatively affect the physicochemical properties of hybrid hydrogels. The use of borax apparently overcomes this problem and permits the incorporation of high concentrations of honey without negative effects. Flexible Application Methods: Can be applied directly onto the wound itself or onto a gauze or foam dressing. The MIC of the combination of honey, cinnamaldehyde and carvacrol was lower than honey alone (0.49µg/mL vs 114.2 μg/mL respectively). The antibacterial activity of the triple combination was reportedly greater than imipenem. In general, enhanced antimicrobial activity was observed when honey was supplemented with propolis. The increase varied depending on the type of honey, concentration of propolis and test micro-organism. Comvita ®Medihoney ® Antibacterial Wound Gel™, Comvita ® Manuka Medihoney ® and Surgihoney™RO ® enhanced the sensitivity of P. aeruginosa to tetracycline.If the area of the wound is showing the classical signs of inflammation: redness, pus, swelling and pain.

Used this on a nasty scald on my husband’s leg... After a week, it's almost completely healed. Now, I’m always using this in the future for broken skin.” - Chris Elliott Activon Tube is 100% pure medical grade manuka honey in a tube. Medical grade manuka honey is natural manuka honey with a very high antibacterial activity that has been sterilized. Activon can be used for treating wounds, burns, scars resulting from surgery, pressure sores, leg ulcers and malodorous wounds.Several researchers have explored the effects of combining honey with antibiotics on antimicrobial activity in vitro. One of the first papers reporting a synergistic effect of honey and antibiotics was published in 1998. The researchers used a broth dilution assay to demonstrate a synergistic effect of an Indian honey (obtained from Phondaghat Pharmacy) and the antibiotics amikacin, ceftazidime and gentamicin against multidrug-resistant clinical isolates of P. aeruginosa. 20 The honey and antibiotics were reportedly tested at a ratio of 1:1. Experiments were also conducted with Klebsiella species, but no synergy was observed with this micro-organism. Later in 2005, another study reported synergy using broth dilution method between an Omani honey (50%) and the antibiotic gentamicin (4µg/mL) against Staphylococcus aureus. 21 Additionally, a study conducted in Egypt reported enhanced effects of antibiotics against clinical isolates of P. aeruginosa, Enterobacter species and Staphylococci in a disc diffusion assay when citrus bee honey (100%) was added to the antibiotic discs (Oxoid). 22 Whether the enhanced antimicrobial effects were synergistic, or additive was not determined in this study.