a) M. R. Heinrich, H. S. Klisa, H. Mayr, W. Steglich and H. Zipse, Angew. Chem., 2003, 115, 4975–4977 ( Angew. Chem., Int. Ed. Engl., 2003, 42, 4826–4828) CrossRef; Up to now relatively few compounds of this type have been made. 42 5 Scope of the Boc 2O/DMAP reagent Due to its excellent reactivity and specificity Boc 2O is a superb reagent for the synthesis of derivatives of amines. Addition of the powerful nucleophilic catalyst DMAP highly increases its reactivity and is accompanied by decreases in selectivity.

a) R. D. Connell, T. Rein, B. Åkermark and P. Helquist, J. Org. Chem., 1988, 53, 3845–3849 CrossRef CAS;

J. R. Henry, L. R. Marcin, M. C. McIntosh, P. M. Scola, G. D. Harris Jr and S. M. Weinreb, Tetrahedron Lett., 1989, 30, 5709–5712 CrossRef CAS. practical, applied ( concerning action or intervention of human will on the real to change it ) Synonym: appliqué Antonyms: spéculatif, théorique Boc 2N-compounds were originally prepared from urethanes with Boc 2O/ DMAP. 13 For amine synthesis from halides alkylation of Boc 2NH is rather convenient. Similarly, alkylation of Cbz(Boc)NH provided a product of type Cbz(Boc)N-R. 34 Reacting an easily obtained Cbz-protected spermidine substrate with Boc 2O/ DMAP ultimately provided N 8-Boc- N 1-Cbz-spermidine via a derivate of this kind, i.e. full discrimination between two primary and one secondary amino functions was accomplished. 35a In the same way Cbz-hydrazine served as a reagent for stepwise alkylation/ acylation of hydrazine. 35b,c Also chiral products of these and related types have been obtained in the presence of a proper ligand. 36 b) L. A. Carpino, E. M. E. Mansour and A. El-Faham, J. Org. Chem., 1993, 58, 4162–4164 CrossRef CAS. This article first appeared in Maritime Risk International, December 2022. Free pratique is permission given by a port for a vessel to enter once it has been certified free of infectious disease by the competent health authorities. It is required for the vessel to be determined legally ready to load or discharge the cargo, thereby allowing the tender of the vessel’s Notice of Readiness (NOR) and is thus important for the calculation of laytime and demurrage.

Many standard form voyage charterparties do just that. In this respect, there a number of different approaches. Some forms use the expression “whether in free pratique or not” or similar – e.g., Gencon 1994, HeavyliftVoy, meaning that the vessel can give the NOR in those circumstances. Of course, by giving the NOR, the Master is affirming that his vessel is ready – if it is not and there will be a delay (i.e., it will be more than a formality), this clause does not allow the tender of the NOR. To that end, this clause replicates what the common law says.

Wordle Helper

a) K. Juhl, N. Gathergood and K. A. Jørgensen, Angew. Chem., 2001, 113, 3083–3085 ( Angew. Chem., Int. Ed. Engl., 2001, 40, 2995–2997) CrossRef; B. Nyasse, L. Grehn, U. Ragnarsson, H. L. S. Maia, L. S. Monteiro, I. Koppel and J. Koppel, J. Chem. Soc., Perkin Trans. 1, 1995, 2025–2031 RSC.